Table 2.
Demographic and clinical characteristics of adult (n = 219) patients with clinical suspicion of TMA: post hoc classification
| Characteristic | Primary aHUS (n = 51) | Trigger-associated aHUS (n = 98) | STEC-HUS (n = 6) | TTP (n = 31) | No TMA (n = 33) |
|---|---|---|---|---|---|
| Age at enrolment (years), mean (SD) | 57.9 (12.6) | 56.3 (17.5) | 55.8 (22.4) | 50.5 (16.7) | 58.3 (19.6) |
| Gender (female), n (%) | 27 (53) | 57 (58) | 4 (67) | 21 (68) | 11 (33) |
| Presenting organ manifestations, n (%) | |||||
| Renal | 43 (84) | 96 (98) | 6 (100) | 22 (71) | 30 (100) |
| Gastrointestinal | 30 (59) | 43 (44) | 5 (83) | 11 (35) | 16 (48) |
| Neurological | 22 (43) | 35 (36) | 3 (50) | 18 (58) | 8 (24) |
| Cardiovascular | 25 (49) | 25 (26) | 3 (50) | 7 (23) | 4 (12) |
| Pulmonary | 21 (41) | 25 (26) | 1 (17) | 4 (13) | 6 (18) |
| Other | 8 (16) | 44 (45) | 2 (33) | 10 (32) | 13 (39) |
| Platelets (×109/L), median (IQR) | 108.0 (71.0–136.0) | 74.0 (38.0–121.0) | 51.5 (34.8–99.0) | 25.0 (10.5–55.0) | 66.0 (22.0–87.0) |
| Haemoglobin reduced below LLN, n (%) | 49 (96) | 92 (94) | 6 (100) | 26 (84) | 29 (88) |
| Serum creatinine (mg/dL), median (IQR) | 1.67 (1.3–3.7) | 2.3 (1.7–3.7) | 3.1 (2.6–4.8) | 1.1 (0.9–1.4) | 2.10a (0.9–4.2) |
| Bilirubin (mg/dL), median (IQR) | 1.0b (0.6–4.3) | 1.0c (0.7–5.6) | 1.4 (0.6–2.3) | 2.1d(1.9–2.8) | 1.1e (0.7–2.2) |
Data presented from an = 23.
b
n = 35.
c
n = 78.
d
n = 21.
e
n = 23 adult patients.
aHUS, atypical haemolytic uraemic syndrome; IQR, interquartile range; LLN, lower limit of normal; SD, standard deviation; STEC-HUS, Shiga toxin-producing Escherichia coli HUS; TTP, thrombotic thrombocytopenic purpura.