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. 2020 Apr 3;14:320. doi: 10.3389/fnins.2020.00320

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Copyright © 2020 Eleftheriou, Wright, Allen, Elijah, Martial and Lucas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in melanopsin-driven responses depending on size of illumination in the degenerated retina. (A) Photograph of retina on MEA, overlaid with a representation of the bar stimulus of increasing width (dark blue bar shows minimal width with sequential increases in width indicated with fine lines on light blue background; figures to left give width in μm). (B,C) Example PSTHs (normalized FR ± SEM) of cells requiring an 800 (B) and 1200 μm (C) wide stimulus to reach maximal response firing rate. (D) Mean (+SEM) change in firing rate as a function of the stimulus bar width. Friedman test with post hoc Dunn’s multiple comparisons test with N = 60 neurons; ****p < 0.0001.