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. 2020 Apr 3;14:320. doi: 10.3389/fnins.2020.00320

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Copyright © 2020 Eleftheriou, Wright, Allen, Elijah, Martial and Lucas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacological isolation of ipRGCs in the degenerated retina. (A) Trial bin counts for two example units that responded to a 10 s light pulse (at time 0; ISI = 120 s) under aCSF (bottom) but then either retained (right) or lost (left) responses under pharmacological block of ionotropic GABA (Picrotoxin and TPMPA), AMPA-type glutamate (DNQX), or gap-junctions (MFA), respectively. (B) Mean (+SEM) fraction of units showing a light response under aCSF and after pharmacological blockade. Two-tailed Mann–Whitney test of averages between aCSF and Picrotoxin and TPMPA (N = 5 retinas, **p = 0.0081), DNQX (N = 4 retinas, *p = 0.0162), and MFA (N = 4 retinas, **p = 0.0031).