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. 2019 Nov 4;7(2):171–180. doi: 10.1093/rb/rbz035

Figure 7.

Figure 7

Cytotoxicity of 4T1 cells co-cultured with different concentrations of free DOX and TP-PEI (DA/DOX)-PEG prodrug micelles at pH 7.4 (A) and 6.8 (B) for 48 h. (C) The volume of tumors treated with saline, free DOX and TP-PEI (DA/DOX)-PEG prodrug micelles over 3 weeks (*P < 0.05, **P < 0.01). (D) The ratio of tumor growth inhibition treated with TP-PEI (DA/DOX)-PEG prodrug micelles and free DOX over 3 weeks (*P < 0.05). (E) The photograph of tumors treated with saline, free DOX and TP-PEI (DA/DOX)-PEG prodrug micelles over 3 weeks. (F) Mice body weights ratio (real-time weight/initial weight), which were treated with saline, free DOX and TP-PEI (DA/DOX)-PEG prodrug micelles in 3 weeks (*P < 0.05; black arrows represented the drug injection)