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. 2020 Mar 20;4(2):e083. doi: 10.1097/EE9.0000000000000083

Figure 2.

Figure 2.

Hypothesized relationships among arsenic metabolism efficiency (AME), urinary arsenic, and CpG methylation. For CpGs that show a positive association with urinary arsenic (hypermethylated CpGs, left panel), higher AME should reduce the internal dose of arsenic and thus show a negative association with CpG methylation. For CpGs negatively associated with urinary arsenic (hypomethylated CpGs, right panel), higher AME should show a positive association with CpG methylation.