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. 2020 Mar 31;104(4):744–753. doi: 10.1097/TP.0000000000003060

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 7. — LP treatment reduced number of F4/80⁺ macrophages and CD3⁺ T cells in the renal allografts. A, Immunohistochemistry for CD3⁺ T-cells (red, upper panel) and F4/80⁺ macrophages (red) is shown in the allograft. Dense interstitial infiltrates were present in the NA and P group and were markedly reduced in the LP-treated recipients. Green is due to the autofluorescence of the tubuli (bar: 100 µm). B, Semi-quantitative analysis confirmed that CD3⁺ T-cell infiltration was reduced by prednisolone and even more by LP treatment (NA; N = 8, P; N = 9, LP; N = 7). F4/80⁺ macrophage infiltration was reduced by LP treatment compared with NA or prednisolone (NA; N = 8, prednisolone; N = 9, LP; N = 6) (mean ± SD. *P < 0.05, **P < 0.01, ****P < 0.0001, NA = no additional treatment, P = Prednisolone, LP = liposomal prednisolone.