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. 2020 Apr 3;11:319. doi: 10.3389/fgene.2020.00319

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Copyright © 2020 Li, Li, Tian, Hu, Le, Wang, Liu and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pyrosequencing results for global LINE-1 methylation assays. (A) No statistically significant correlations were observed between global LINE-1 methylation with age based on linear regression analysis (P < 0.5586). (B) No statistically significant correlations were observed between global LINE-1 methylation with age based on ANOVA analysis (P = 0.5602) and unpaired t-tests between the three age groups (<30 years of age, 30–40 years of age, >40 years of age).