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. 2020 Apr 3;11:319. doi: 10.3389/fgene.2020.00319

TABLE 3.

Regression of Fertilization (2 pronuclei) rate and good-quality embryo rate on rDNA promoter methylation level (mean values or individual CpG unit).

rDNA promoter methylation level (mean values or CpG unit) Fertilization (2 pronuclei) rate Good-quality embryo rate on day 3
Mean methylation values of all CpG units 0.2350 (P = 0.0707) 0.0954 (P = 0.4684)
Mean methylation values measured using primerS1 0.2070 (P = 0.1126) 0.0754 (P = 0.5670)
Mean methylation values measured using primerS2 0.2528 (P = 0.0513) 0.1002 (P = 0.4461)
Mean methylation values measured using primerS3 0.1857 (P = 0.1555) 0.0874 (P = 0.5068)
CpG_1 0.2274 (P = 0.0806) 0.0446 (P = 0.7354)
CpG_2 0.0336 (P = 0.7987) 0.0988 (P = 0.4526)
CpG_3 0.2371 (P = 0.0682) 0.0649 (P = 0.6223)
CpG_4 0.2316 (P = 0.0749) 0.0867 (P = 0.5100)
CpG_5 0.1108 (P = 0.3995) 0.0852 (P = 0.5176)
CpG_6 0.2419 (P = 0.0626) 0.1042 (P = 0.4283)
CpG_7 0.2512 (P = 0.0529) 0.1354 (P = 0.3022)
CpG_8 0.2459 (P = 0.0582) 0.0763 (P = 0.5623)
CpG_9 0.2010 (P = 0.1235) 0.1026 (P = 0.4354)
CpG_10 0.3055 (P = 0.0176)* 0.1383 (P = 0.2920)
CpG_11 0.2613 (P = 0.0438)* 0.0475 (P = 0.7185)
CpG_12 0.2049 (P = 0.1163) 0.1024 (P = 0.4360)
CpG_13 0.2032 (P = 0.1194) 0.0790 (P = 0.5484)
CpG_14 0.2928 (P = 0.0232)* 0.1041 (P = 0.4287)
CpG_15 0.1988 (P = 0.1278) 0.0945 (P = 0.4727)
CpG_16 0.1412 (P = 0.2820) 0.0450 (P = 0.7329)
CpG_17 0.1866 (P = 0.1534) 0.0894 (P = 0.4971)
CpG_18 0.1515 (P = 0.2479) 0.0854 (P = 0.5166)
CpG_19 0.1891 (P = 0.1480) 0.0738 (P = 0.5750)
CpG_20 0.2147 (P = 0.0995) 0.0947 (P = 0.4716)
CpG_21 0.1951 (P = 0.1352) 0.0848 (P = 0.5194)

*P < 0.05.