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. 2020 Apr 3;11:575. doi: 10.3389/fimmu.2020.00575

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Copyright © 2020 Zhou, Yuan, Zhang, Guo, Li, Li, Xiong and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of Th17 activation of the regional immune system in the intestinal tract. Th17 cells play an important role in the activation of the regional immune system induced by the intestinal flora. Bacteria and their products are recognized by receptors expressed on the surface of various immune cells by direct adhesion or translocation to the lamina propria, thereby inducing various cytokines and chemokines, and activating the intestinal mucosal immune system. Molecules recognized by TLR receptors promote the secretion of cytokines, hence promoting the differentiation of Th17 cells. Th17 cells secrete cytokines to promote the activation of inflammatory pathways in immune cells and recruit macrophages.