. 2020 Feb 5;27(e1):e87–e92. doi: 10.1136/ejhpharm-2019-002076

Table 2.

Cumulative amount of vancomycin infused over 24 hours at 25°C (n=5 syringes), infused at 0.8 mL/hour for vancomycin syringes at 25 mg/mL and at 2 mL/hour for vancomycin syringes at 40–60 and 80 mg/mL

Vancomycin concentration (mg/mL)	Solvent for reconstitution	Cumulative quantity (mg) at 24 hours, median (IQR) (% loss±SD)		P value
				WFI vs saline solution		F vs NF
		With filter	Without filter	F	NF	F vs NF
25	WFI	452 (2) (6.2±0.8)	444 (5) (7.1±0.6)	0.063	0.905	0.071
25	Saline solution	447 (2) (7.1±0.5)	448 (4) (7.1±1.6)	0.063	0.905	0.690
40	WFI	1663 (5) (13.5±0.5)	1662 (4) (13.4±0.1)	0.012*	0.008*	0.802
40	Saline solution	1645 (6) (14.3±0.3)	1651 (8) (14.0±0.6)	0.012*	0.008*	0.087
60	WFI	2563 (2) (11.0±0.3)	2601 (10) (9.7±0.2)	0.012*	0.008*	0.008*
60	Saline solution	2531 (4) (12.1±0.4)	2550 (1) (11.5±1.1)	0.012*	0.008*	0.012*
80	WFI	3314 (4) (13.7±0.1)	3284 (1) (14.4±0.3)	NA	NA	0.012*
80	Saline solution	NA	NA	NA	NA	NA

*P<0.05.

F, filtered; NA, not applied; NF, non-filtered; WFI, water for injection.