Table 3.

Pharmacokinetic parameters for meropenem and piperacillin obtained from Css determinations

	Css (mg/l) Mean±SD	P value (ANOVA)	CL (ml/kg.min) Mean±SD	P value (ANOVA)	AUC (μg.h/ml) Mean±SD	P value (ANOVA)
Meropenem (n=Css determinations)
(A) Dose adjustment not required and no CRRT (n=26)	20.7±10.3	<0.0001	3.2±1.6	<0.0001*	74.6±37.9	<0.0001
(B) Dose adjustment required and no CRRT (n=6)	65.5±25.4		0.8±0.3		234.3±91.4
(C) With CRRT (n=9)	39.8±16.4		1.18±0.3		139.8±59.1
All cases (n=41)	30.8±21.4		2.43±1.7		110.8±76.9
Piperacillin
(A) Dose adjustment not required and no CRRT (n=63)	72.5±46.8	<0.0001†	3.8±2.6	<0.0001†	261.0±168.4	<0.0001†
(B) Dose adjustment required and no CRRT (n=24)	138.6±44.5		1.1±0.5		499.1±160.1
(C) With CRRT (n=40)	138.4±57.9		1.2±0.6		498.2±208.6
All cases (n=127)	108.8±59.0		2,5±2.0		380.0±212.5

*Differences not statistically significant between groups B and C.

†Differences not statistically significant between groups B and C.

AUC, area under the curve; CL, clearance; CRRT, continuous renal replacement therapy; Css, serum concentration at steady state.