Table 1.
Positive selection signals of each SNP
| No.a | rsID | Chr | Pos.b | P-valc | Tajima’s D | |DDAF| | FST | XPCLR | |UiHS| | |UXPEHH| | Sum | Protective or risk |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| c7 | rs7951870 | 11 | 46 373 311 | 8.25 E-11 | 2 | 7 | 3 | 5 | 2 | 5 | 24 | Risk |
| b18 | rs11223651 | 11 | 133 841 034 | 2.42 E-11 | 7 | 0 | 3 | 2 | 5 | 1 | 18 | Risk |
| f7 | rs7801375 | 7 | 131 567 263 | 2.26 E-08 | 4 | 4 | 3 | 3 | 1 | 3 | 18 | Protective |
| c18 | rs4766428 | 12 | 110 723 245 | 7.09 E-10 | 3 | 6 | 0 | 5 | 0 | 3 | 17 | Risk |
| e8 | rs9922678 | 16 | 9 946 319 | 6.72 E-09 | 3 | 6 | 1 | 1 | 4 | 1 | 16 | Protective |
| c12 | rs11577346 | 1 | 150 066 530 | 1.47 E-09 | 5 | 0 | 4 | 3 | 1 | 2 | 15 | Protective |
| e9 | rs2068012 | 14 | 30 190 316 | 4.14 E-08 | 6 | 0 | 0 | 0 | 7 | 2 | 15 | Risk |
| a8 | rs4391122 | 5 | 60 598 543 | 1.73 E-13 | 3 | 6 | 0 | 3 | 1 | 2 | 15 | Risk |
| a11 | rs4702 | 15 | 91 426 560 | 2.30 E-12 | 0 | 4 | 0 | 3 | 4 | 4 | 15 | Protective |
| b1 | rs7893279 | 10 | 18 745 105 | 3.56 E-11 | 0 | 0 | 1 | 4 | 9 | 1 | 15 | Protective |
Note: Five SNPs were risk and the other 5 SNPs are protective from schizophrenia. Each number refers to total positive selection signals of all 14 populations for each SNP.
|DDAF|, derived allele frequency; FST, fixation index; XPCLR, cross-population composite likelihood ratio; |UiHS|, integrated haplotype score; |UXPEHH|, cross-population extended haplotype homozygosity.
aTen SNPs exceeded the threshold of 15 positive selection signals to be statistically significant.
bThe UCSC hg19/NCBI build 37 position of the SNP.
cThe P-values of the SNP from the PGC2-SCZ GWAS.