Table 3.
Changes of Aspartate Transaminase and Alanine Transaminase
| Variables | Before Propensity Score Matching | After Propensity Score Matching | ||||
|---|---|---|---|---|---|---|
| INHA (n=592) | TIVA (n=138) | P value | INHA (n=376) | TIVA (n=94) | P value | |
| AST change (%) | −4.20 (−24.4–35.0) | −8.25 (−27.3–15.7) | 0.038 | −6.2 (−25–21.5) | −8.0 (−26.2–11.0) | 0.324 |
| ALT change (%) | −10.0 (−27.9–10.2) | −16.2 (−31.9– −3.8) | 0.004 | −12.0 (−28.6–6.5) | −16.7 (−32– −4) | 0.025 |
| Pre-operative | ||||||
| AST (U/L) | 44 (34–58) | 51 (38–76) | <0.001 | 45 (36–58.5) | 54 (38–82) | 0.001 |
| ALT (U/L) | 51 (41–70) | 65 (46–95) | <0.001 | 50 (39.5–69) | 75 (53–116) | <0.001 |
| Post-operative | ||||||
| AST (U/L) | 43 (31–68.5) | 51 (34–76) | 0.072 | 43 (31–66) | 52.5 (38–82) | 0.016 |
| ALT (U/L) | 46 (31–71) | 51.5 (35–88) | 0.030 | 43 (30.5–66) | 61 (39–109) | <0.001 |
| Peak value within 3 days after surgery | ||||||
| AST (U/L) | 44.5 (32–71) | 54 (38–81) | 0.008 | 44 (31–68) | 54.5 (47.5–89) | 0.013 |
| ALT (U/L) | 48 (31–73) | 57.5 (36–92) | 0.005 | 44 (31–68) | 62.5 (41–115) | <0.001 |
Notes: Values are median (interquartile range) or number of patient (%). AST change, the change in AST levels measured within 24 hrs before and after surgery; ALT change, the change in ALT levels measured within 24 hrs before and after surgery.
Abbreviations: INHA, inhalation anesthesia group; TIVA, total intravenous group; ALT, alanine transaminase; AST, aspartate transaminase; ULN, upper limit of normal.