Table 2.
Result of Cox Regression Analyses for Primary Outcome After Percutaneous Coronary Intervention
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| Unadjusted HR [95% CI] | p-value | Adjusted HR [95% CI] | p-value | |
| Time-fixed variables | ||||
| Sex, male | 0.98 [0.88–1.08] | 0.646 | 1.06 [0.95–1.19] | 0.292 |
| Age, per 5 years | 1.07 [1.05–1.10] | < 0.001 | 1.07 [1.04–1.10] | < 0.001 |
| Hypertension | 1.09 [0.93–1.27] | 0.302 | 1.02 [0.87–1.20] | 0.082 |
| Diabetes mellitus | 1.34 [1.20–1.48] | < 0.001 | 1.33 [1.19–1.47] | < 0.001 |
| Atrial fibrillation | 1.27 [1.08–1.50] | < 0.001 | 1.16 [0.98–1.37] | 0.090 |
| Myocardial infarction | 1.42 [1.28–1.57] | < 0.001 | 1.42 [1.29–1.58] | < 0.001 |
| Household Income | ||||
| Low | 1 (Ref) | – | 1 (Ref) | – |
| Middle | 0.99 [0.87–1.12] | 0.863 | 1.03 [0.91–1.17] | 0.637 |
| High | 1.05 [0.92–1.19] | 0.456 | 1.08 [0.95–1.23] | 0.243 |
| Time-dependent Variables | ||||
| Antiplatelets | ||||
| No aspirin, no ADPRB | 1 (Ref) | – | 1 (Ref) | – |
| Aspirin only | 0.49 [0.42–0.57] | < 0.001 | 0.71 [0.59–0.85] | < 0.001 |
| ADPRB only | 0.58 [0.46–0.72] | < 0.001 | 0.82 [0.64–1.05] | 0.120 |
| Aspirin plus ADPRB | 0.69 [0.60–0.80] | < 0.001 | 1.03 [0.86–1.23] | 0.730 |
| Statins | ||||
| No statin | 1 (Ref) | – | 1 (Ref) | – |
| Statin use | 0.69 [0.62–0.78] | < 0.001 | 0.72 [0.63–0.81] | < 0.001 |
| Withdrawal | 1.90 [1.56–2.32] | < 0.001 | 1.87 [1.52–2.29] | < 0.001 |
Note: Data are derived from multivariate time-dependent Cox proportional hazard regression model.
Abbreviations: ADPRB, adenosine diphosphate receptor blocker (clopidogrel, prasugrel, ticlopidine, ticagrelor); CI, confidence interval; HR, hazard ratio.