. Author manuscript; available in PMC: 2021 Feb 1.

Published in final edited form as: Am Heart J. 2019 Dec 5;220:224–236. doi: 10.1016/j.ahj.2019.11.017

Table 3.

WISE-CVD Invasive Coronary Reactivity Testing

	CRT only N=276	CRT and Baseline CMRI, N=231	p-value

Invasive Measures	Mean ± SD	Mean ± SD
LVEDP	14.4 ± 5.0	14.3 ± 5.0	0.3
CFR	2.7 ± 0.6	2.7 ± 0.7	0.4
ΔCBF	65.9 ± 85.2	70.8 ± 89.6	0.1
ΔACH	− 0.35 ± 15.0	− 0.22 ± 15.1	0.8
ΔCPT	2.7 ± 12.4	2.8 ± 12.5	0.8
ΔNTG	14.7 ± 13.7	14.9 ± 13.8	0.6
Abnormal CRT Pathway	N (%)	N (%)
CFR < 2.5	97 (37.5)	81 (37.5)	1.0
ΔCBF ≤ 50%	109 (54.0)	89 (51.7)	0.1
ΔACH ≤ 0%	115 (48.1)	95 (47.3)	0.6
ΔCPT ≤ 0%	97 (42.9)	82 (43.2)	0.9
ΔNTG ≤ 20%	155 (65.4)	132 (66.0)	0.5

CRT, coronary reactivity testing; CMRI, cardiac magnetic resonance imaging. LVEDP=Left Ventricle End-Diastolic Pressure; CFR=coronary flow reserve in response to adenosine; ΔCBF=% coronary blood flow change in response to acetylcholine; ΔACH=% diameter change in response to acetylcholine; ΔCPT diameter change in response to cold pressor test; ΔNTG=% diameter change in response to nitroglycerin.