Skip to main content
. 2009 Oct 17;21:35–68. doi: 10.1016/S0959-6380(09)70029-7

Table 2.

Anticancer Activity of Some Representative RENS

REN Structure Tumor (Cell Line) Antitumor Activity (GI50)* μM REN Structure Tumor (Cell Line) Antitum or Activity (GI50)* μM
Inline graphic
 Leukemia (CCRF-CEM) 0.12 Inline graphic
 Leukemia (CCRF-CEM) 2.49
Lung (non-SC) (A549/ATCC) 6.44 Lung (non-SC) (A549/ATCC) 3.43
Colon (Colo 205) 1.49 Colon (Colo 205) 4.43
CNS (SF-295) 6.03 CNS (SF-295) 1.67
Melanoma (M14) 1.91 Melanoma (Ml 4) 1.71
Ovarian (IGROV1) 5.13 Ovarian (IGROV1) 3.61
Renal (UO-31) 6.4 Renal (UO-31) 6.99
Prostate (PC-3/Du-45) 4.46/8.79 Prostate (Du-45) 3.05
Breast (MCF-7) 1.47 Breast (MCF-7) 1.79
Inline graphic
 Leukemia (K-562) 1.79 Inline graphic
 Leukemia (CCRF-CEM) 1.32
Lung (non-SC) (HOP-62)) 0.41 Lung (non-SC) (HOP-92) < 0.01
Colon (Colo 205) 1.20 Colon (Colo 205) 3.78
CNS (SF-295) 1.02 CNS (SF-295) 3.38
Melanoma (M14) 1.81 Melanoma (M14) 6.79
Ovarian (IGROV1) 3.59 Ovarian (IGROV1) 3.54
Renal (UO-31) 5.54 Renal (UO-31) 4.0
Prostate (PC-3/Du-45) 1.61/8.83 Prostate (PC-3/Du-45) 2.25/4.01
Breast (MCF-7) 1.46 Breast (MCF-7) 3.99
Inline graphic
 Lung (non-SC) Inline graphic
 Lung (non-SC)
(A549) 4.30 (A549) 2.0
(H-460) 3.0 (H-460) 1.5
Breast (MCF-7) 5.5 Breast (MCF-7) 2.5
Prostate (PC-3) 3.5 Prostate (PC-3) 2.0
graphic file with name fx17.gif Lung (non-SC) IC50 (μM) graphic file with name fx18.gif Lung (non-SC) IC50 (μM)
(A549) 9.1 (A549) 1.70
(H-460) 6.5 (H-460) 1.45
Breast (MCF-7) 19 Breast (MCF-7) 2.15
Prostate (PC-3) 0.8 Prostate (PC-3) 2.01
Ovarian (OVCAR-3) 1.17
*

GI50=concentration of the compound required to reduce the tumor growth by 50%