Table 1.
Clinical and Demographic characteristics of women with pPROM.
| Negative culture (n=10) | Positive culture (n=7) | p-value | |
|---|---|---|---|
| Maternal age (years; median [IQR])a | 26.5 (25.3–31.3) | 33 (28.5–33.5) | 0.46 |
| Body mass index (kg/m2; median [IQR])a | 29.1 (23.8–33.7) | 32 (24.6–36.6)c | 0.85 |
| Primiparityb | 30% (3/10) | 0% (0/7) | 0.23 |
| Race/Ethnicityb | 0.74 | ||
| African-American | 80% (8/10) | 71.4% (5/7) | |
| White | 10% (1/10) | 28.6% (2/7) | |
| Other | 10% (1/10) | 0% (0/7) | |
| Gestational age at amniocentesis (weeks; median [IQR])a | 30.6 (26–33) | 25.6 (22.6–31.9) | 0.65 |
| IL-6 (ng/mL; median [IQR])a | 0.2 (0.1–0.4) | 102.8 (22–125.3) | 0.003 |
| Amniotic Fluid Glucose (mg/dl; median [IQR])a | 33.5 (23–41) | 10 (1–15) | 0.003 |
| Amniotic Fluid WBC (cells/mm3; median [IQR])a | 1.5 (0–3.5) | 60 (7.5–319.5) | 0.007 |
| Gestational age at membrane rupture (weeks; median [IQR])a | 30.5 (26–32.9) | 25.4 (22.5–31.9) | 0.67 |
| Gestational age at delivery (weeks; median [IQR])a | 33 (28.4–33.9) | 25.7 (23.1–32.1) | 0.38 |
| Cesarean sectionb | 10% (1/10) | 14.3% (1/7) | 1.0 |
| Birthweight (grams; median [IQR])a | 1725 (1127.5–1850) | 840 (527–2025) | 0.88 |
| Acute maternal inflammatory responseb | |||
| Stage 1 (Early acute subchorionitis or chorionitis) | 40% (4/10) | 0% (0/6)d | 0.23 |
| Stage 2 (Acute chorioamnionitis) | 30% (3/10) | 16.7% (1/6)d | 1.0 |
| Stage 3 (Necrotizing chorioamnionitis) | 0% (0/10) | 50% (3/6)d | 0.036 |
| Acute fetal inflammatory responseb | |||
| Stage 1 (Chorionic vasculitis or umbilical phlebitis) | 20% (2/10) | 50% (3/6)d | 0.3 |
| Stage 2 (Umbilical arteritis) | 10%(1/10) | 16.7 % (1/6)d | 1.0 |
| Stage 3 (Necrotizing funisitis) | 10% (1/10) | 0% (0/6)d | 1.0 |
Data are given as median (interquartile range, IQR) and percentage (n/N).
a
Mann-Whitney test.
b
Fisher’s exact test
c
Two missing data.
d
One missing data.
Abbreviations: pPROM, preterm prelabor rupture of membranes; WBC, white blood cells