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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Stroke. 2020 Mar 4;51(4):1135–1141. doi: 10.1161/STROKEAHA.119.028406

Table 2. Multivariable modeling of associations between pre-ICH SSRI use and ICH risk.

Regression models for ICH and subtypes were adjusted for the listed covariates. Presence of APOE2 and E4 alleles were included in lobar ICH models only. Significance was set at p< 0.05. Abbreviations: %, percent; APOE, apolipoprotein E; BMI, body mass index; CI, confidence interval; ICH, intracerebral hemorrhage; NDRI, norepinephrine–dopamine reuptake inhibitor; OR, odds ratio; SARI, Serotonin antagonist and reuptake inhibitors; SNRI, serotonin–norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.

Predictor Any ICH Lobar ICH Non-lobar ICH
OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
SSRI 0.824 (0.632, 1.074) 0.152 0.952 (0.669, 1.355) 0.785 0.724 (0.528, 0.992) 0.044
SNRI 0.480 (0.296, 0.778) 0.003 0.594 (0.313, 1.127) 0.111 0.387 (0.211, 0.713) 0.002
SARI 0.767 (0.46, 1.277) 0.308 1.080 (0.568, 2.053) 0.814 0.605 (0.320, 1.144) 0.122
NDRI 0.340 (0.16, 0.722) 0.005 0.201 (0.047, 0.851) 0.029 0.442 (0.191, 1.023) 0.057
Tricyclic 1.060 (0.596, 1.882) 0.843 1.394 (0.661, 2.938) 0.383 0.847 (0.425, 1.689) 0.637
Tetracyclic 1.194 (0.442, 3.224) 0.727 1.530 (0.498, 4.695) 0.458 0.757 (0.219, 2.615) 0.660
Antiplatelet 0.776 (0.682, 0.884) <0.001 0.893 (0.739, 1.080) 0.244 0.717 (0.618, 0.831) <0.001
Anticoagulant 2.491 (1.871, 3.315) <0.001 2.445 (1.712, 3.491) <0.001 2.543 (1.837, 3.520) <0.001
BMI 0.983 (0.974, 0.991) <0.001 0.967 (0.954, 0.981) <0.001 0.989 (0.979, 0.999) 0.026
Prior Stroke 6.556 (4.57, 9.404) <0.001 5.722 (3.706, 8.836) <0.001 7.033 (4.801, 10.302) <0.001
Depression 1.041 (0.878, 1.234) 0.646 1.247 (0.981, 1.587) 0.072 0.984 (0.810, 1.196) 0.87
Heart Disease 1.180 (0.985, 1.414) 0.073 1.384 (1.087, 1.764) 0.009 1.053 (0.852, 1.302) 0.631
Hypertension 3.614 (3.148, 4.151) <0.001 2.246 (1.835, 2.749) <0.001 4.635 (3.942, 5.449) <0.001
High Cholesterol 0.533 (0.467, 0.608) <0.001 0.655 (0.540, 0.795) <0.001 0.503 (0.434, 0.584) <0.001
Heavy Alcohol Use 1.680 (1.389, 2.031) <0.001 1.257 (0.940, 1.681) 0.122 1.903 (1.546, 2.343) <0.001
Illicit Drug Use 1.605 (1.250, 2.060) <0.001 1.376 (0.931, 2.033) 0.109 1.778 (1.353, 2.336) <0.001
APOE2 allele N/A N/A 1.232 (0.974, 1.559) 0.083 N/A N/A
APOE4 allele N/A N/A 1.422 (1.177, 1.719) <0.001 N/A N/A