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. Author manuscript; available in PMC: 2021 Mar 9.
Published in final edited form as: J Mammary Gland Biol Neoplasia. 2020 Mar 9;25(1):51–68. doi: 10.1007/s10911-020-09446-3

Fig. 4: E2-induces R-loop formation in human explants.

Fig. 4:

Representative images of S9.6 immunofluorescence in (a) basal and (b) E2-treated explants. (c) Quantification of R-loop foci per nucleus in basal and luminal epithelial cells demonstrates increased R-loop formation with E2-treatment relative to T=0 or basal explants (n =5 for T=0 and each treatment group). (d) R-loop foci per nucleus in Basal and 10nM E2 explants from 5 donors. Error bars indicate SEM. Significance was determined using ANOVA (** p<0.01).