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. Author manuscript; available in PMC: 2020 Apr 10.
Published in final edited form as: Nat Med. 2019 Dec 5;25(12):1822–1832. doi: 10.1038/s41591-019-0675-0

Fig. 3 |. Inflammatory model of immunosenescence and chronic disease.

Fig. 3 |

This proposed model associates elevated baseline phosphorylated signaling proteins (for example, phosphorylated STAT (pSTAT) levels) with cellular unresponsiveness and chronically elevated inflammatory activity. The model involves an elevation of baseline pSTAT levels and its association with hallmark phenomenon of immunosenescence, an increased pro-inflammatory environment, unresponsive cells and a clinical impact on immune response. (Adapted with permission from ref.22, Elsevier.)