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. 2020 Apr 10;15(4):e0231254. doi: 10.1371/journal.pone.0231254

Table 4. Risk of various events in those with possible and probable HF, compared with definite HF.

Definite HF Possible HF* Probable HF p-value
A. CHD
Event Proportion, no. of events /no. at risk, (%) § 77/479 (16) 20/135 (15) 16/121 (13)
Age-and-sex-adjusted Hazards Ratio (CI) 1.00 REFERENT 0.95 (0.58–1.56) 0.69 (0.41–1.19) 0.31
Multivariable-adjusted Hazards Ratio (CI) || 1.00 REFERENT 0.98 (0.57–1.67) 0.63 (0.35–1.12) 0.26
B. Other CVD
Event Proportion, no. of events /no. at risk, (%) § 66/479 (14) 18/135 (13) 19/121 (16) N/A
Age-and-sex-adjusted Hazards Ratio (CI) 1.00 REFERENT 0.95 (0.56–1.60) 0.96 (0.58–1.61) 0.82
Multivariable-adjusted Hazards Ratio (CI) || 1.00 REFERENT 1.01 (0.58–1.76) 1.03 (0.61–1.75) 0.92
C. Death
Event Proportion, no. of events /no. at risk, (%) § 429/479 (90) 122/135 (90) 106/121 (88) N/A
Age-and-sex-adjusted Hazards Ratio (CI) 1.00 REFERENT 1.13 (0.93–1.39) 0.84 (0.68–1.04) 0.74
Multivariable-adjusted Hazards Ratio (CI) || 1.00 REFERENT 1.21 (0.97–1.51) 0.83 (0.66–1.05) 0.97

* Meet HF criteria but have an alternative explanation for findings.

Do not meet full criteria for definite HF.

p-value for whether either pre-HF category as a whole predicts time to the outcome.

§ Event proportions are based on overall sample.

|| Model adjusted for age, sex, SBP, antihypertensive medications, current smoking, prevalent CHD, and body mass index.

HF = heart failure; CHD = coronary heart disease; CVD = cardiovascular disease.