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. 2020 Apr 10;6(15):eaax5150. doi: 10.1126/sciadv.aax5150

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Fig. 3 — (A) Distribution of differentially regulated transcripts (black), differentially regulated transcripts with a cryptic signature (red), and unchanged transcripts (gray) in Nkx2.5;1^KO2^KO compared with 1^FF2^FF E10.5 PHTs. (B and C) Normalized exon-level expression values for citrate synthase (CS; B) and Ndufb9 (C) in Nkx2.5;1^KO2^KO and 1^FF2^FF E10.5 PHTs. (D to G) PANTHER analysis (D and E) and Gene Set Enrichment Analysis (GSEA) (F and G) of differentially regulated, identified cryptic transcripts. (H and I) 5′ rapid amplification of complementary DNA (cDNA) ends (5′RACE) for CS (F) and Ndufb9 (E). Left: 5′RACE products (black, canonical; blue/green, alternative). Right: Alignment of sequenced products. TSS^C, canonical TSS; TSS^A#, alternative TSS; ns, not significant; FWER, Family-wise error rate; Pol II, polymerase II.