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. 2020 Apr 10;6(15):eaax5150. doi: 10.1126/sciadv.aax5150

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Fig. 4 — (A and B) H3K23ac (A) and H4K16 (B) staining on Nkx2.5;1^KO2^KO and 1^FF2^FF E10.5 sagittal sections at AVC level with cardiac troponin (cTnT) and Hoechst counterstains. Grayscale images are unedited. (C to E) ChIP-qPCR showing relative enrichment (TSS^A versus TSS^C) of Hdac1and Hdac2 at CS TSS^A (C) and Ndufb9 TSS^A1 (D), TSS^A2 (E), normalized to immunoglobulin G (IgG). (F to I) H3K36me3 (E), H3K23ac (F), H3K14ac (G), and H4K16ac (H) ChIP-qPCR showing relative enrichment over TSS^C/TSS^As for CS and Ndufb9 in Nkx2.5;1^KO2^KO and 1^FF2^FF E10.5 PHTs. (J) Hdac1/Hdac2 controls cardiomyocyte development at a critical metabolic checkpoint. CHD, chromodomain containing subunit. WT, wild type.