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. Author manuscript; available in PMC: 2020 Aug 12.
Published in final edited form as: Nature. 2020 Feb 12;580(7802):283–287. doi: 10.1038/s41586-020-2043-0

Figure 1. Filamentous tau pathology of CBD.

Figure 1.

(a-f), Staining of neuronal inclusions, neuropil threads and astrocytic plaques in the frontal cortex of CBD cases 1–3 by antibody RD4 (specific for 4R tau, brown) (a-c), and in the frontal cortex of case 3 by antibody AT8 (pS202, pT205 tau, brown) (e) and Gallyas-Braak silver (black) (f). Staining of frontal cortex from CBD cases 1–3 was negative when antibody RD3 (specific for 3R tau) was used (d). Nuclei were counterstained in blue. Scale bars, 50 μm. (g), Immunoblots using antibodies RD4, RD3 and AT8 of sarkosyl-insoluble tau extracted from the frontal cortex of CBD cases 1–3. (h), Negative-stain electron micrographs of Type I (narrow) and Type II (wide) tau filaments extracted from the frontal cortex of CBD case 1. Scale bar, 50 nm.