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. 2020 Apr 10;10:6245. doi: 10.1038/s41598-020-63361-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment network for Oc- vs.St-PVAT comparison. The enrichment network shows the pathway/GO-BP gene-sets (nodes) that are significantly associated (FDR < 0.05) either with Oc- or St-PVAT. The node color refers to the association with the phenotype (Oc-PVAT, red; St-PVAT, blue); node gradient color is proportional to the gene-set normalized enrichment score (NES), from lower (light) to higher (dark); node size is proportional to the gene-set size. Edges connect related pathways/GO-BPs. Edge thickness is proportional to the similarity between two pathway/GO-BP, for a cut-off = 0.15 of the combined Jaccard plus Overlap coefficient. To simplify network reading, only relevant gene-sets are labeled with the name reported in Reactome or GO-BP gene-set collection. Enrichment network was drawn using the Enrichment Map software v.3.2.0, implemented as a plug-in in the Cytoscape v.3.7.0 platform.