Table 4.
Subtype | Envelope | IC50 (µg/mL) | |||||
---|---|---|---|---|---|---|---|
CAP256-VRC26.08 | CAP256-VRC26.09 | ||||||
HEK produced mAbs | N. benthamiana (ΔXTFT) produced mAbs without TPST coexpression | N. benthamiana (ΔXTFT) produced mAbs with TPST coexpression | HEK produced mAbs | N. benthamiana (ΔXTFT) produced mAbs without TPST coexpression | N. benthamiana (ΔXTFT) produced mAbs with TPST coexpression | ||
C | Du172.17 | >50 | >50 | >50 | >50 | >50 | >50 |
Du156.12 | 0.020 | 0.56 | 0.020 | 0.039 | 0.34 | 0.030 | |
ZM233.6 | 0.0032 | >50 | 0.002 | 0.052 | >50 | 0.015 | |
Du422.01 | 0.0024 | 0.22 | 0.0014 | 0.047 | 0.36 | 0.03 | |
ZM197.7 | 0.019 | 0.21 | 0.034 | 0.019 | 0.52 | 0.015 | |
ZM249.1 | 0.053 | 0.47 | 0.054 | 0.036 | 0.42 | 0.027 | |
CAP45.G3 | 4.86 | 18.28 | 7.68 | 8.12 | 46.03 | 15.73 | |
CAP214.15 | 1.33 | 5.16 | 1.38 | 0.28 | 3.97 | 0.30 | |
B | 6535 | >50 | >50 | >50 | >50 | >50 | >50 |
PVO.4 | 8.22 | >50 | 7.83 | >50 | >50 | >50 | |
TRO.11 | >50 | >50 | >50 | >50 | >50 | >50 | |
QH0692.42 | >50 | >50 | >50 | >50 | >50 | >50 | |
A | Q168.a2 | 0.14 | 3.53 | 0.59 | 0.22 | 5.48 | 0.33 |
Q23.17 | 2.78 | >50 | 1.10 | 4.93 | >50 | 2.34 | |
Q842.d12 | >50 | >50 | >50 | 5.06 | >50 | 6.32 | |
Q461.e2 | 1.48 | 5.71 | 1.26 | 0.74 | >50 | 1.00 |
*Note: Dlata shown above are means of two independent experiments.