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. 2020 Apr 10;10:6201. doi: 10.1038/s41598-020-63052-1

Table 4.

HIV-1 neutralising activity of CAP256-VRC26 bNAbs produced in N. benthamiana (ΔXTFT).

Subtype Envelope IC50 (µg/mL)
CAP256-VRC26.08 CAP256-VRC26.09
HEK produced mAbs N. benthamiana (ΔXTFT) produced mAbs without TPST coexpression N. benthamiana (ΔXTFT) produced mAbs with TPST coexpression HEK produced mAbs N. benthamiana (ΔXTFT) produced mAbs without TPST coexpression N. benthamiana (ΔXTFT) produced mAbs with TPST coexpression
C Du172.17 >50 >50 >50 >50 >50 >50
Du156.12 0.020 0.56 0.020 0.039 0.34 0.030
ZM233.6 0.0032 >50 0.002 0.052 >50 0.015
Du422.01 0.0024 0.22 0.0014 0.047 0.36 0.03
ZM197.7 0.019 0.21 0.034 0.019 0.52 0.015
ZM249.1 0.053 0.47 0.054 0.036 0.42 0.027
CAP45.G3 4.86 18.28 7.68 8.12 46.03 15.73
CAP214.15 1.33 5.16 1.38 0.28 3.97 0.30
B 6535 >50 >50 >50 >50 >50 >50
PVO.4 8.22 >50 7.83 >50 >50 >50
TRO.11 >50 >50 >50 >50 >50 >50
QH0692.42 >50 >50 >50 >50 >50 >50
A Q168.a2 0.14 3.53 0.59 0.22 5.48 0.33
Q23.17 2.78 >50 1.10 4.93 >50 2.34
Q842.d12 >50 >50 >50 5.06 >50 6.32
Q461.e2 1.48 5.71 1.26 0.74 >50 1.00

*Note: Dlata shown above are means of two independent experiments.