Table 4.

Immune related proteins modulated exclusively in the hemolymph of D. polymorpha challenged with RNA poly I:C. The BLAST annotation and expect value are derived from the sequence similarity search against NCBInr database. H= hemocytes and P= plasma and the fold change of significantly modulated proteins (p-value < 0.05) between treated and control sample is indicated.

BLAST annotation (NCBInr)			RNA poly I:C
Immune proteins	E-value	Conserved domain	H	P
Pattern recognition receptors (PRRs)
Peptidoglycan-recognition protein	1.9E-40	Peptidoglycan recognition proteins, lysozyme domain	—	−1.5
Beta-galactoside-binding lectin	2.0E-13	Galactoside-binding lectin	—	−1.5
Immune signaling
Granulin	1.0E-28	Granulin domain	—	1.7
cell-adhesion
Cadherin-23 (Otocadherin)	1.2E-205	Cadherin repeat-like domains	—	3.2
cadherin-like protein	0.0E + 00	Cadherin repeat-like domains	—	2.9
fibronectin-like protein	4.0E-59	Fibronectin type III domain, Immunoglobulin domain	—	2
Immune effectors
Proteases, protease inhibitors and hydrolases
Cathepsin K	5.4E-28	Papain family cysteine protease	−1.3	—
Alpha-2-macroglobulin	2.7E-07		—	1.6
Serpin B6	1.3E-38	SERine Proteinase INhibitors	—	−1.8
Lysosomal alpha-mannosidase	0.0E + 00	Glycosyl hydrolases family 38 C-terminal domain, Alpha mannosidase, N-terminal catalytic domain ofcore-specific lysosomal alpha 1,6-mannosidas	—	−1.4
Antiviral proteins?
Ectonucleotide pyrophosphatase /phosphodiesterase	0.0E + 00	Ectonucleotide pyrophosphatase/phosphodiesterase, DNA/RNA non-specific endonuclease	—	4.6
Spliceosome RNA helicase	7.4E-31	DEAD box helicase domain	−1.5	-
Thaumatin-like protein	3.7E-83	antifungal thaumatin-like domain	—	−1.5
Mucin-like protein	7.5E-56	Anthrax Toxin Receptor, Herpes virus major outer envelope glycoprotein (BLLF1), Endomucin domain	—	2.2
Complement system
complement factor B-like protein	1.2E-04	Trypsin-like serine protease	—	2.7
Complement C1q tumor necrosis factor	3.8E-04	C1q domain	—	−1.4