Table 5.
Effect of statin treatment duration on cognition.
| Reaction time (n = 1,510) | B | SE | CI 95% | P |
|---|---|---|---|---|
| Short-term users vs controls | −0.007 | 0.044 | −0.092, 0.079 | =0.880 |
| Medium-term users vs controls | −0.011 | 0.040 | −0.089, 0.067 | =0.784 |
| Long-term users vs controls | −0.015 | 0.039 | −0.092, 0.061 | =0.700 |
| Short-term users vs medium-term users | 0.004 | 0.025 | −0.045, 0.054 | =0.866 |
| Short-term users vs long-term users | 0.008 | 0.024 | −0.039, 0.056 | =0.726 |
| Medium-term users vs long-term users | 0.004 | 0.017 | −0.029, 0.037 | =0.803 |
| Working memory (n = 1,480) | B | SE | CI 95% | P |
| Short-term users vs controls | −0.051 | 0.105 | −0.256, 0.154 | =0.627 |
| Medium-term users vs controls | 0.055 | 0.075 | −0.093, 0.202 | =0.466 |
| Long-term users vs controls | −0.030 | 0.059 | −0.145, 0.084 | =0.604 |
| Short-term users vs medium-term users | −0.106 | 0.122 | −0.345, 0.134 | =0.387 |
| Short-term users vs long-term users | −0.021 | 0.112 | −0.240, 0.199 | =0.854 |
| Medium-term users vs long-term users | 0.085 | 0.083 | −0.078, 0.248 | =0.306 |
| Fluid intelligence (n = 1,477) | B | SE | CI 95% | P |
| Short-term users vs controls | −0.488 | 0.596 | −1.655, 0.679 | =0.413 |
| Medium-term users vs controls | 0.507 | 0.516 | −0.504, 1.518 | =0.325 |
| Long-term users vs controls | 0.110 | 0.506 | −0.882, 1.103 | =0.828 |
| Short-term users vs medium-term users | −0.371 | 0.339 | −1.034, 0.293 | =0.274 |
| Short-term users vs long-term users | −0.167 | 0.313 | −0.780, 0.447 | =0.594 |
| Medium-term users vs long-term users | 0.204 | 0.252 | −0.290, 0.698 | =0.419 |
Statistical test results from the analysis of performance of controls, short-term statin users (1–4 years), medium-term statin users (5–10 years) and long-term statin users (>10 years) at the third assessment in the three cognitive tests measuring reaction time (card game “Snap”), working memory (“Pairs matching test”) and reasoning abilities (“Fluid intelligence test”), adjusted for covariates (reaction time: sex, age, education, physical activity, sleep duration, alcohol intake, smoking status, angina, hypertension, cholesterol-lowering and anti-hypertension medication; working memory: sex, age, education, BMI, physical activity and hypertension; fluid intelligence: sex, age, education, physical activity, sleep duration, alcohol intake, heart attack, angina and cholesterol-lowering medication). Generalised linear models and correction for multiple comparisons have been applied. B = regression coefficient, SE = standard error, CI 95% = 95% confidence interval (min, max). The threshold for significance was set at P < 0.017.