Table 1.
Comparison of well-known published human metabolic networks from three databases, VHM, BIGG, and HMR databases.
| Models | Transcripts | Genes | Reactions | Metabolites | Dead-end Metabolites | Blocked-Reactions | Database | Publication Date | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Recon1 | 1905 | 1496 | 3741 | 2766 | 342 | 1274 | BIGG1 | 2007 | 10 |
| HMR2.0 | — | 3765 | 8181 | 6006 | 499 | 608 | HMR2 | 2014 | 15 |
| Recon2.02 | 2191 | 1786 | 7440 | 5063 | 1178 | 1603 | VMH3 | 2013 | 12 |
| Recon3D_VMH | 3697 | 3290 | 13543 | 8399 | 888 | 1582 | VMH | 2018 | 13 |
| Recon3D_BIGG | 2248 | 1884 | 10600 | 5835 | 0 | 0 | BIGG | 2018 | 13 |
1Biochemical, Genetic and Genomic knowledge base (http://bigg.ucsd.edu).
2The Human Metabolic Reaction (http://www.metabolicatlas.org/).
3Virtual Metabolic Human (https://vmh.life).