Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 10;10:6211. doi: 10.1038/s41598-020-63344-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Phenotypic variations of human immune cells after C. albicans challenge. (A) Representative C. albicans immune-aggregates by light microscopy observation showing cell migration gradients (CM) and compact inflammatory aggregates (IA) 6 days after challenge with Caal93, Caal121 and Caal123 clinical isolates. Bars represent 50 μm. (B) Phenotypic modification of immune cells induced by C. albicans. Flow cytometry data from each subject over the three months period was concatenated and analyzed on tSNE FlowJo module. Representative unsupervised tSNE clustering of immune cells for one subject before (day 0) and after C. albicans challenge (day 6) showing phenotypic clustering of CD66+ (beige), CD14+ (red), CD4+ (light blue), CD8+ (dark blue) immune cells (n = 16). (C) tSNE phenotypic signatures induced in immune cells after challenge by Caal93, Caal121 and Caal123 clinical isolates according to CI outcome (fungal burdens lower than 100 CFU/ ml by day 6) and PI outcome (fungal burdens higher than 100 CFU/ ml by day 6). CD66+ (beige), CD14+ (red), CD4+ (light blue), CD8+ (dark blue) immune cells (n = 16).