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. 2020 Apr 10;10:6169. doi: 10.1038/s41598-020-63263-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visual Abstract of whole blood miRNA profiling by miR-Seq and plasma miRNA profiling by miRNA rt-PCR array in the TRILOGY-ACS cohort and plasma profiling by Nanostring in the Singapore cohorts. Samples in the whole blood TRILOGY cohort (N = 153) and the plasma Singapore cohorts (N = 96) were collected following 7 days of maintenance clopidogrel (Baseline). Platelet-poor plasma samples for the TRILOGY cohort targeted array were collected at Baseline (N = 878), at 30 days of either clopidogrel or prasugrel anti-platelet therapy (N = 466), or at 6 months of clopidogrel or prasugrel therapy (N = 435). *: −3p or −5p miRNA strand.