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. 2020 Apr 10;10:6197. doi: 10.1038/s41598-020-63279-y

Table 2.

Univariate and multivariate Cox regression analyses of overall survival and disease-free survival in GC patients.

Variables Univariate analyses Multivariate analyses
Hazard ratio 95% CI P Hazard ratio 95% CI P
Overall survival
Age (years) ≥ 60/<60 0.805 0.638–1.169 0.881
Gender Male/female 0.942 0.596–1.283 0.755
Tumor size (cm) ≥ 5/<5 1.753 1.279–2.861 0.018 2.097 1.192–2.252 0.036
Differentiation grade Poor+ moderate/well 3.134 1.369–3.693 0.007 2.013 1.145–2.598 0.016
TNM stage III/I + II 1.547 0.546–2.286 0.398
Depth of invasion pT3-4/pT1-2 1.783 0.693–3.810 0.332
Lymph node metastasis Yes/no 2.842 1.361–2.578 0.033 2.333 1.567–2.679 0.045
Distant metastasis Yes/no 3.161 1.527–3.967 0.013 1.783 0.574–2.788 0.357
CEA, µg/ml ≥ 4.5/<4.5 1.807 0.837–3.835 0.273
CA19-9, kU/L ≥ 40/<40 1.655 0.973–3.691 0.803
MiR-520f-3p expression low/high 2.31 1.524–3.429 0.025 1.946 1.256–2.678 0.031
Disease-free survival
Age (years) ≥ 60/<60 0.854 0.525–1.809 0.624
Gender Male/female 0.742 0.739–1.507 0.203
Tumor size (cm) ≥ 5/<5 1.265 0.562-2.952 0.815
Differentiation grade Poor+ moderate/well 3.798 1.337–3.531 0.034 1.525 1.545–2.852 0.041
TNM stage III/I + II 1.891 0.818–2.437 0.825
Depth of invasion pT3-4/pT1-2 1.827 1.236–2.099 0.017 1.901 1.311–2.633 0.027
Lymph node metastasis Yes/no 3.272 1.433–4.629 0.018 1.587 1.211–2.094 0.021
Distant metastasis Yes/no 2.357 1.307–3.752 0.015 2.464 1.238–2.359 0.047
CEA, µg/ml ≥ 4.5/<4.5 1.676 0.804–1.122 0.107
CA19-9, kU/L ≥ 40/<40 1.423 0.457–1.669 0.438
MiR-520f-3p expression low/high 2.225 1.896–3.833 0.013 1.876 1.292–2.867 0.039

CA19-9 carbohydrate antigen 19-9; HR, hazard ratio; 95% CI, 95% confidence interval.