Table 1.
Dose, RBE and LETd metrics reported as median and range over the patient group for the different RBE models and OARs.
| Structure | median (Range) [keV/µm] | RBE model | D50 median (Range) [Gy(RBE)] | D2% median (Range) [Gy(RBE)] | median (Range) | RBE2% median (Range) |
|---|---|---|---|---|---|---|
| RBE1.1 | 0.7 (0.4–1.7) | 8.5 (6.0–16.0) | — | — | ||
| Heart | 13.0 (9.6–15.0) | MCN3.0Gy | 0.9 (0.6–2.4) | 11.6 (8.5–20.3) | 1.62 (1.53–1.65) | 1.51 (1.40–1.56) |
| ROR3.0Gy | 0.9 (0.6–2.3) | 11.2 (8.2–19.6) | 1.56 (1.47–1.59) | 1.46 (1.35–1.51) | ||
| RBE1.1 | 54.3 (52.8–54.6) | 55.4 (55.1–55.6) | — | — | ||
| Brainstem | 1.8 (1.8–1.9) (CSI) | MCN2.1Gy | 58.1 (56.8–58.5) | 59.8 (59.3–60.4) | 1.18 (1.17–1.18) | 1.18 (1.18–1.20) |
| 2.2 (2.1–2.3) (boost) | ROR2.1Gy | 56.5 (55.2–56.8) | 57.9 (57.5–58.3) | 1.14 (1.14–1.15) | 1.15 (1.14–1.16) | |
| RBE1.1 | 4.0 (2.2–4.8) | 20.4 (17.6–21.4) | — | — | ||
| Lungs | 4.8 (3.9–5.2) | MCN4.0Gy | 4.7 (2.5–5.6) | 22.6 (19.6–23.6) | 1.27 (1.24–1.29) | 1.22 (1.20–1.23) |
| ROR4.0Gy | 4.6 (2.4–5.5) | 22.1 (19.2–23.1) | 1.25 (1.23–1.27) | 1.20 (1.18–1.20) | ||
| RBE1.1 | 3.9 (1.2–8.4) | 14.0 (6.2–18.7) | — | — | ||
| Thyroid | 4.5 (4.1–6.1) | MCN3.0Gy | 5.2 (1.7–10.5) | 17.6 (9.4–22.2) | 1.44 (1.36–1.67) | 1.40 (1.31–1.66) |
| ROR3.0Gy | 5.1 (1.7–10.3) | 17.1 (9.0–21.6) | 1.42 (1.34–1.61) | 1.36 (1.27–1.58) |
Results for the variable RBE models are reported for the nominal (α/β)x values, indicated by subscripts in the table.