. 2019 Dec 13;9(2):114–121. doi: 10.1007/s13730-019-00437-w

Table 2.

Review of previous report on carboplatin-related acute interstitial nephritis and comparison with this case

Age	Sex	Malignancy	Treatment regimen of cisplatin administered before carboplatin	Treatment regimen of carboplatin	Serum creatinine (mg/dL)	Renal pathological features	Therapeutic intervention and renal prognosis	References
54	Female	Anaplastic ovarian carcinoma	6 courses of intravenous therapy (60 mg/m²) 6 courses of intraperitoneal therapy (200 mg/m²)	4 courses of intraperitoneal therapy (200 mg/m² for the first course, and 300 mg/m² for the next three cycles)	0.9 → 8.2 within 7 days	In the interstitium, a moderate number of lymphocytes, plasma cells, and eosinophils diffusely surrounding the tubules were infiltrated. The pathologic findings were consistent with focal, moderate interstitial nephritis	Oral prednisone was administered at a dose of 60 mg/day for 4 weeks. The serum creatinine decreased to 4.3 mg/dL	[12]
62	Female	Serous cystadenocarcinoma of the ovary	6 courses of intravenous therapy (50 mg/m²) 6 courses of intraperitoneal therapy (200 mg/m² for the first 4 cycles, and 100 mg/m² for the last 2 treatments)	5 courses of intraperitoneal therapy (200 mg/m² for the first course, and 300 mg/m² for the last 4 cycles)	1.3 → 9.5 within 5 days	Marked tubular atrophy was present. The interstitium was markedly edematous and contained a mild, but diffuse, infiltration of mononuclear cells with focal areas of interstitial hemorrhage	Prednisone at a dose of 60 mg/day was initiated orally for a 4-week course Finally, her serum creatinine recovered to 2.0 mg/dL	[12]
53	Male	Pancreatic neuroendocrine tumor	1 course of intravenous therapy (60 mg/m²)	1 course of intravenous therapy (300 mg)	1.24 → 6.81 within 8 days	A large number of inflammatory cells infiltrated into the interstitium. The major population of infiltrating cells was mononuclear cells. Eosinophils and plasma cells were few. Immunostaining of surface markers was observed mainly with CD3 and CD68 positive cells	Oral prednisolone was started at a dose of 40 mg/day. The steroids were remarkably effective, and the serum creatinine level decreased to 1.43 mg/dL 15 days after treatment	This case

Age

Sex

Malignancy

Treatment regimen of cisplatin administered before carboplatin

Treatment regimen of carboplatin

Serum creatinine (mg/dL)

Renal pathological features

Therapeutic intervention and renal prognosis

References

Female

Anaplastic ovarian carcinoma

6 courses of intravenous therapy (60 mg/m²)

6 courses of intraperitoneal therapy (200 mg/m²)

4 courses of intraperitoneal therapy (200 mg/m² for the first course, and 300 mg/m² for the next three cycles)

0.9 → 8.2 within 7 days

In the interstitium, a moderate number of lymphocytes, plasma cells, and eosinophils diffusely surrounding the tubules were infiltrated. The pathologic findings were consistent with focal, moderate interstitial nephritis

Oral prednisone was administered at a dose of 60 mg/day for 4 weeks. The serum creatinine decreased to 4.3 mg/dL

[12]

Female

Serous cystadenocarcinoma of the ovary

6 courses of intravenous therapy (50 mg/m²)

6 courses of intraperitoneal therapy (200 mg/m² for the first 4 cycles, and

100 mg/m² for the last 2 treatments)

5 courses of intraperitoneal therapy

(200 mg/m² for the first course, and 300 mg/m² for the last 4 cycles)

1.3 → 9.5 within 5 days

Marked tubular atrophy was present. The interstitium was markedly edematous and contained a mild, but diffuse, infiltration of mononuclear cells with focal areas of interstitial hemorrhage

Prednisone at a dose of 60 mg/day was initiated orally for a 4-week course

Finally, her serum creatinine recovered to 2.0 mg/dL

[12]

Male

Pancreatic neuroendocrine tumor

1 course of intravenous therapy (60 mg/m²)

1 course of intravenous therapy (300 mg)

1.24 → 6.81 within 8 days

A large number of inflammatory cells infiltrated into the interstitium. The major population of infiltrating cells was mononuclear cells. Eosinophils and plasma cells were few. Immunostaining of surface markers was observed mainly with CD3 and CD68 positive cells

Oral prednisolone was started at a dose of 40 mg/day. The steroids were remarkably effective, and the serum creatinine level decreased to 1.43 mg/dL 15 days after treatment

This case