Table 2. Hazard Ratios for Cardiovascular Event Occurrence in the Primary, Secondary, and Sensitivity Analyses, With Various Ways to Determine Glomerular Hyperfiltrationa.
| Analysis | Unadjusted models | Adjusted modelsb | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Primary analysis | ||||
| GHF stratified by sex and age | 1.71 (1.20-2.44) | .003 | 1.88 (1.30-2.74) | .001 |
| Sensitivity analyses | ||||
| GHF stratified by sex, age, and race | 1.62 (1.12-2.34) | .01 | 1.69 (1.15-2.46) | .008 |
| GHF stratified by sex, age, and smoking status | 1.56 (1.08-2.24) | .03 | 1.71 (1.04-2.80) | .03 |
| GHF stratified by sex, age, and obesity | 1.55 (1.06-2.26) | .02 | 1.59 (1.06-2.39) | .02 |
| Propensity score matching analysis | ||||
| GHF stratified by sex and age | 2.20 (1.44-4.24) | .02 | NA | NA |
Abbreviations: GHF, glomerular hyperfiltration; NA, not applicable.
a
Hazard ratios are calculated using Cox regression analyses and represent comparison with individuals with normal glomerular filtration.
b
Adjusted models included age, sex, African American race, active smoking, body mass index, lean body mass, fasting glucose level, low-density lipoprotein cholesterol level, total cholesterol level, mean arterial pressure, and heart rate. The adjusted model was not computed for the propensity score analysis as appropriate covariable balance was achieved.