. 2020 Mar 6;9(3):112. doi: 10.3390/antibiotics9030112

Table 2.

Characteristics of 29 fosfomycin-resistant E. coli isolates: genotype, clinical characteristics, and amino acid alterations in genes associated with fosfomycin resistance.

Isolate No.	CC ^a	ST ^a	Allele no. ^b	Specimen	Site of Infection ^c	Mode of Acquisition ^d	Amino Acid Alterations
Isolate No.	CC ^a	ST ^a	Allele no. ^b	Specimen	Site of Infection ^c	Mode of Acquisition ^d	fos	GlpT	UhpT	MurA
S020	CC131	ST131	53-40-47-13-36-28-29	Blood	IAI	Hospital
S074		ST131	53-40-47-13-36-28-29	Blood	UTI	Hospital		D220N
C072		ST131-slv1	53-40-193-13-36-28-29	Blood	Cholangitis	Community
C073		ST131-slv2	53-40-47-200-36-28-29	Blood	UTI	LTCF
A011		ST131-dlv1	53-35-47-13-36-5-29	Blood	IAI	Hospital
C025	CC14	ST1193	14-14-10-200-17-7-10	Urine	UTI	Community
C036		ST1193	14-14-10-200-17-7-10	Blood	Cholangitis	Community		G168R
A049		ST1193	14-14-10-200-17-7-10	Blood	UTI	Community		M136K
S019		ST1193	14-14-10-200-17-7-10	Blood	Prostatitis	LTCF
C078		ST1193-slv	14-40-10-200-17-7-10	Blood	UTI	Community
C106	CC69	ST106	21-38-27-6-5-8-4	Blood	UTI	Community
A004	CC69	ST106-dlv	21-88-27-6-5-79-4	Blood	UTI	Community	fosA3
A031	CC95	ST1531-slv	37-35-19-37-17-5-26	Blood	UTI	Community		A16T
A041	CC95	ST1531-slv	37-35-19-37-17-5-26	Blood	UTI	LTCF		A16T
C011	CC155	ST58	64-4-16-24-8-14	Blood	Liver abscess	Community			Y60F
C045	CC38	ST38	4-26-2-25-5-5-19	Urine	UTI	Hospital		Ins. of DG139
C063	CC10	ST10	10-11-4-8-8-8-2	Urine	UTI	Hospital	fosA3	G168R		P99S
A043	CC398	ST398-slv	64-40-1-1-8-8-6	Blood	Cholangitis	Hospital				A154T
S050	CC95	ST95-slv	37-38-34-37-17-11-26	Blood	NF	Hospital		A16T

^a CC, clonal complex; ST, sequence type. ^b adk-fumc-gyrB-icd-mdh-purA-recA, slv, single-locus variant; dlv, double-locus variant. The allele number different from the most closely related ST was underlined. ^c UTI, urinary tract infection; IAI, intraabdominal infection; NF, neutropenic fever. ^d LTCF, long-term care facility.