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. 2020 Feb 27;8(3):44. doi: 10.3390/biomedicines8030044

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Causal mediation model of the total effect of APOA2 rs3813627 on HDL and APOA1 levels through BMI. The mediation effect of APOA2 rs3813627 risk genotype carriage on low HDL and APOA1 levels through BMI (assessed on the overweight/obese individuals, n = 95 subjects for HDL and n = 65 for APOA1) after adjusting by sex. Path-weights are displayed as beta values with standard errors in brackets. Asterisks indicate significant p-values (* p < 0.05). Significance of the indirect effect was determined using mean bootstrapped. (a) Direct effect of rs3813627 on BMI; (b) Direct effect of BMI on parameters (HDL and APOA1 levels); (c) Total effect of rs3813627 on parameters (HDL and APOA1 levels) through BMI; (c´) Direct effect of rs3813627 on parameters (HDL, and APOA1 levels) removing BMI. Abbreviations: BMI, body mass index; HDL, high density lipoprotein; APOA1, apolipoprotein type A1.