Table 5.
Genotypic and allelic frequencies APOA2 rs3813627 polymorphism.
| Condition/Models | Codominant | Dominant | Recessive | Log-Additive | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) het |
OR (95% CI) hom |
p | OR (95% CI) |
p | OR (95% CI) |
p | OR (95% CI) |
p | |
| HDL | |||||||||
| Model 1 | 0.64 (0.24–1.74) |
3.09 (0.85–11.21) |
0.065 | 1.02 (0.43–2.45) |
0.956 | 3.76 (1.11–12.71) |
0.030 * | 1.42 (0.77–2.62) |
0.256 |
| Model 2 | 0.62 (0.22–1.69) |
3.03 (0.81–11.29) |
0.066 | 0.99 (0.41–2.40) |
0.979 | 3.76 (1.09–13.02) |
0.033 * | 1.40 (0.75–2.60) |
0.288 |
| APOA1 | |||||||||
| Model 1 | 0.45 (0.12–1.75) |
2.77 (0.71–10.88) |
0.055 | 0.97 (0.33–2.86) |
0.952 | 3.89 (1.10–13.81) |
0.035 * | 1.49 (0.74–3.03) | 0.265 |
| Model 2 | 0.46 (0.12–1.76) |
2.82 (0.71–11.12) |
0.054 | 0.98 (0.33–2.89) |
0.964 | 3.94 (1.11–14.08) |
0.034 * | 1.50 (0.74–3.06) |
0.257 |
Multiple logistic regression analysis of the APOA2 rs3813627 polymorphism was carried out in overweight/obese individuals (BMI ≥ 25 kg/m2), taking the APOA2 rs3813627 variant as independent variables an HDL (n = 91) and APOA1 levels (n = 65) as dependent variables. The APOA2 rs3813627 GG genotype was considered as the reference category. Model 1 was carried out without adjusting and Model 2 was performed after adjusting by sex (* p < 0.05). The multiple logistic regression analysis was analyzed to determine the risk associated with low HDL and APOA1 levels. Abbreviations: BMI, body mass index; HDL, high density lipoprotein; APOA1, apolipoprotein type A1; OR, odds ratio; CI, confidence interval.