Table 7.
General information about SNPs in APOA1 and APOA2 on lipid traits.
| SNP | Gene | MAF * (Risk Allele) | Lipid Traits |
|---|---|---|---|
| rs3813627 | APOA2 | 0.31 (T) | Susceptibility to low HDL levels [19]. |
| rs5085 | APOA2 | 0.18 (G) | Marginally associated with total cholesterol levels and waist-to-hip ratio [36]. |
| rs5082 | APOA2 | 0.24 (G) | Associated with BMI and food consumption, [17,37], with lower total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol [38] and regulates postprandial response to a saturated fat overload [23]. |
| rs6413453 | APOA2 | 0.10 (A) | Probably associated with weight [36]. |
| rs670 | APOA1 | 0.19 (T) | Associated with increased levels of LDL-c and total cholesterol [39], metabolic syndrome [40] and blood glucose levels [41]. |
| rs1799837 | APOA1 | 0.01 (T) | Associated with high triglycerides and insulin levels after a high-carbohydrate diet [42]. |
* MAF in all populations. Abbreviations: high-density lipoprotein (HDL); low-density lipoprotein (LDL); minor allele frequency (MAF); apolipoprotein type 1 (APOA1) and 2 (APOA2).