Table 1.
Toxicity of approved cytostatic drugs according to World Health Organization (WHO) classification.
| Grade | 0 | 1 | 2 | 3 | 4 |
|---|---|---|---|---|---|
| Intensity | none | mild | moderate | severe | life-threatening or disabling |
| 1. Bone marrow & blood a | |||||
| Hb | > 11 | 10–11 | 8–9 | 7–8 | < 6.5 |
| Leucocytes | > 4 | 3–4 | 2–3 | 1–2 | < 1.0 |
| Granulocytes | > 2 | 1–2 | 1 | 0.5–0.9 | < 0.5 |
| Thrombocytes | > 100 | 75–99 | 50–74 | 25–49 | < 25 |
| 2. GI Tract | |||||
| Liver GOT/GPT | < 1.25 × N b | 1.25–2,5 × N | 2.6–5 × N | 5.1–10 × N | > 10 × N |
| Bilirubin | < 1.25 × N | 1.25–2.5 × N | 2.6–5 × N | 5.1–10 × N | >10 × N |
| 3. Kidney | |||||
| Urea | < 1.25 × N b | 1.25–2.5 × N | 2.6–5 × N | 5.1–10 × N | > 10 × N |
| Kreatinin | < 1.25 × N | 1.25–2.5 × N | 2.6–5 × N | 5.1–10 × N | > 10 × N |
| Proteinuria | none | < 3 g/L | 3–10 g/L | > 10 g/L | ne syn |
| 4. Fever d | none | < 38 °C | 38–40 °C | > 40 °C | pr dec |
a Hb = hemoglobin (g/100 mL); cells (× 109/L); b N = norm value; c ne syn = nephrotic syndrome; chemotherapy (Mit. C) induced hemolytic-uremic syndrome (c-HUS) with letality between 44 and 82%; d pr dec = fever caused by therapy and not by the tumor, combined with blood pressure decrease (hypotony). GI = gastrointestinal tract; GOT = glutamate-oxalacetate-transaminase; GPT = glutamate-pyruvate-transaminase.