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Expression of CYP1A1 alleles in budding yeast activates BaP-DHD and AFB1 to become potent genotoxins. Growth of the rad4 rad51 strain expressing CYP1A1 (A,D), CYP1A1 I462V (B,E), CYP1A1 T461N (C,F) was measured in real-time after exposure to either AFB1 (top) or BaP-DHD (bottom). A600 is plotted against time (hrs).
