Table V.
COMPARISON OF MUCOSAL AND SYSTEMIC ASC RESPONSES AND PROTECTIVE IMMUNITY INDUCED BY VIRULENT, ATTENUATED AND INACTIVATED ROTAVIRUS VACCINES IN NEONATAL PIGS AT PCD 0 (PID 21)a
| Mean No. ASC/5 ⊠ 105 MNC |
Percent protection against rotavirus challenge |
|||||||
|---|---|---|---|---|---|---|---|---|
| Virus inoculum group | Intestinal lamina propria | Peripheral blood lymphocytes | Diarrhea | Shedding | ||||
| IgG | IgA | G/Ab | IgG | IgA | G/Ab | |||
| Live | ||||||||
| Virulent rotavirus (PO) | 64 | 53 | 1.2 | 2 | 6 | 0.3 | 89% | 100% |
| Attenuated rotavirus (PO) | 41 | 6 | 6.8 | 2 | 1 | 2 | 44% | 19% |
| Inactivated | ||||||||
| Rotavirus (PO) | 0.7 | 5 | 0.14 | 88 | 1 | 88 | 0% | 0% |
| Rotavirus (IM) | 4 | 3 | 1.3 | 237 | 2 | 119 | 17% | 0% |
| Controls | <1 | <1 | <1 | <1 | 14% | 0% | ||
a
Data summarized from Yuan et al., (1996, 1998); Saif et al., (1996, p. 199).
b
G/A, ratio of IgG to IgA ASCs.