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. 2009 May 15:208–246. doi: 10.1016/B0-72-168903-5/50014-8

TABLE 9-7.

Drugs That Have Been Documented or Suspected to Cause Cholestasis or Hepatic Enzyme Induction Resulting in Increased Serum Alkaline Phosphatase (SAP) Levels

  • Anabolic steroids/androgens

  • Asparaginase

  • Azathioprine

  • Barbiturates (important)

  • Cephalosporins

  • Cyclophosphamide

  • Dapsone

  • Erythromycin estolate

  • Estrogens

  • Glucocorticoids (important in dogs only)

  • Gold salts

  • Griseofulvin

  • Halothane

  • Ibuprofen

  • 6-Mercaptopurine

  • Methimazole

  • Methotrexate

  • Nitrofurantoin

  • Oxacillin

  • Oxymetholone

  • Phenobarbital (important)

  • Phenothiazines

  • Phenylbutazone

  • Phenytoin

  • Primidone (important)

  • Progesterone

  • Salicylates

  • Sulfur

  • Testosterone

  • Tetracyclines

  • Thiabendazole

  • Trimethoprim-sulfa drug

  • Vitamin A

NOTE: Those drugs that most reliably increase SAP are marked (important). The other drugs are less consistent.