TABLE 10-1.

Basic Types of Hypersensitivity Reactions^a

	Hypersensitivity type
item	1	2	3	4
Designation	Anaphylactic	Cytotoxic	Immune complex	Delayed—cell mediated
Time course
Initiation	Minutes	Minutes	3–6 hours	18–24 hours
Persistence	Minutes	Dependent on antigen	Dependent on antigen	Weeks
		and antibody	and antibody
Transfer with	IgE	IgM, IgG	IgG	T lymphocytes
Complement required	No	Usually	Yes	No
Histamine dependent	Yes	No	No	No
Histology	Edema, congestion,	Cell destruction,	Necrosis, neutrophils,	Lymphocytes,
	eosinophils	phagocytosis	later plasma cells	macrophages, necrosis
Viral immunopathological	Minor	Minor	Major	Major in brain, lung
effects	?some rashes	?some rashes	acute: fever
			chronic: immune
			complex disease

^aAs categorized by Gell and Coombs.