TABLE III.
Replication of RNA Viruses
| Virus | Form of RNA | Source of nucleic polymerase | Nature of polymerase activity | Presence of polymerase in virion | Viral replication site within host cell | |
|---|---|---|---|---|---|---|
| A | Paramyxovirus, Rhabdovirus | ssa (–), unsegmented | Viral | RNA-dependent RNA polymerase (RDRP) | + | Cytoplasm |
| B. | Bunyavirus, Arenavirus | ssc(±), segmented | Viral | RDRP | + | Cytoplasm |
| C. | Orthomyxovirus (Influenza virus) | ss (–), segmented | Viral | RDRP | + | Nucleus |
| D. | Rotavirus, Reovirus, Orbivirus | dsb(±), segmented | Viral | RDRP | + | Cytoplasm |
| E. | Picornavirus (Poliovirus, Hepatitis A), Togavirus (Sindbis virus), Coronavirus | ss (+), unsegmented | Viral | RDRP | – | Cytoplasm |
| F. | Retrovirus, (HIV) | ss (+), unsegmented, diploid | Viral | Reverse transcriptase | + | Nucleus |
a
ss = single-stranded.
b
ds = double-stranded; + or – indicates positive or negative polarity.
c
± = ambisense genome.