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. 2020 Mar 19;117(14):7917–7928. doi: 10.1073/pnas.1918659117

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Fig. 4. — Synteny analysis of rearranged centromeres with wild-type H99 centromeres reveals complex rearrangements. (A–G) A pairwise comparison of newly generated and wild-type centromeres revealed that translocations are mediated by double-strand breaks (DSBs) generated via CRISPR. Centromere-specific events are described in the individual panels. Gray shades represent direct synteny, while the cyan shade represents inversion events. In the cases that are shown in detail, the cross represents the evidence for HR, whereas the connecting gray lines represent joining events marking NHEJ. VYD135-CEN7 was generated after artificial fusion of two contigs and hence was not analyzed in detail.