TABLE 1.3.
Viruses Within a Family that Use Unrelated Receptors
| Family | Virus | High-affinity receptor | Accessory receptor |
|---|---|---|---|
| Herpesviridae | |||
| Alpha | Herpes simplex | HIgR (CD155 family) | Heparan sulfate |
| HVEM (TNF receptor family) | |||
| Pseudorabies | 140 kD heparan sulfate proteoglycan | ||
| 85 kD integral membrane protein | |||
| CD155 and related proteins | |||
| Beta | Cytomegalovirus | protein?? unidentified | Heparan sulfate |
| Gamma | Bovine herpesvirus | 56 kD protein | Heparan sulfate |
| Epstein Barr | CD21 (CR2 receptor) | ||
| Coronaviridae | |||
| Group 1 | |||
| Porcine | TGEVa | Porcine APN: aminopeptidase N | |
| Feline | FIPVa | Feline APN: aminopeptidase N | |
| Human | 229e | Human APN: human aminopeptidase N | |
| Human | NL63 | ACE2: Human angiotensin-converting enzyme 2 | |
| Group 2 | |||
| Human | SARS | ACE2: Human angiotensin-converting enzyme 2 | |
| Murine | Mouse hepatitis | CEACAM1: Carcinoembryonic antigen-related cell adhesion molecule 1b | |
| Bovine | Bovine coronavirus | Sialic acid residues on glycoproteins and glycolipids |
a
Virus abbreviation: TGEV, transmissible gastroenteritis virus (of swine); FIPV, feline infectious peritonitis virus.
b
Note that entry of mouse hepatitis variants of extended host range is independent of CEACAM1, and instead uses heparan sulfate as an entry receptor.