TABLE 1.4.
Viruses That Bind to Heparin-Like Glycosaminoglycans
| Virus | Family | High affinity receptor |
|---|---|---|
| RNA viruses | ||
| Sindbis | Togaviridae | High affinity laminin receptor |
| Dengue | Flaviviridae | ??? |
| Hepatitis C | Flaviviridae | CD81 |
| Foot and mouth disease | Picornaviridae | αvβ3 integrin |
| Respiratory syncytial | Paramyxoviridae | ??? |
| Retroviruses | ||
| HIV-1 | Retroviridae | CD4 (Ig superfamily) |
| DNA viruses | ||
| Vaccinia | Poxviridae | EGF receptor ??? |
| Human papillomavirus | Papillomaviridae | Syndecan-1a |
| Herpes simplex | Herpesviridae | HIgR (CD155 family) |
| Adeno-associated type 2 | Parvoviridae | FGFR1 |
Abbreviations used: EGF receptor, epidermal growth factor receptor; HIgR, herpes immunoglobulin-like receptor; CD155, the poliovirus receptor; FGFR1, human fibroblast growth factor receptor 1.
a
In this case the heparan sulfate proteoglycan appears to be the primary receptor protein.