Fig. 5.

Schematic model for the formation of Sup35NM oligomers and fibrils. Unstructured Sup35NM monomers (red) are converted to ∼1.7-nm oligomers and then to 3∼4-nm oligomers. Fluctuating disordered structures are depicted as tail-like shapes. Globular and oligomer core parts are shown as spherical shapes. Core structures of fibrils (dark blue) are surrounded by some mobile structures (pale blue). The unstructured monomer is incorporated into a growing end of the fibrils. The attached unstructured monomer is conformationally converted to a core to become a newly elongated part of the fibril (orange).