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Expression and methylation level in carcinoma and paracarcinoma samples of ccRCC. (a) mRNA expression of LRG1 in carcinoma and paracarcinoma tissues (p < 0.01, n = 6) detected by qPCR. (b, c) Protein expression of LRG1 in carcinoma and paracarcinoma tissues (p < 0.01, n = 6) detected by western blot. (d) LRG1 methylation level of CpG1 and CpG2 is downregulated in ccRCC tissue (p < 0.0001).
